Common Drugs & Their Antidotes

DrugAntidote
Acetaminophen/Tylenol/Paracetamolacetylcysteine (Mucomyst)
Anticholinergics, diphenhydramine, dimenhydrinatePhysostigmine
Anticholinesteraseatrophine sulfate or pralidoxime
AntifreezeFomepizole, Ethanol
Arsenic, Copper, Lead, MercuryD-Penicillamine (Cuprimine )
Benzodiazepinesflumazenil
Beta-Blocking agents, Calcium channel blockers, Hypoglycemia, Hypoglycemic agentsGlucagon, Epinephrine
Calcium Channel BlockersCalcium Chloride, Glucagon
Coumadin/WarfarinPhytonadione or Vitamin K
CyanideAmyl nitrite, sodium nitrite, sodium thiosulfate
CyclophosphamideMesna
DigoxinDigibind or Digoxin Immune Fab
Dopaminephentolamie (Regitine)
Ethylene glycolfomepizole
ethyllene poisoningantizol
Extrapyramidal symptoms (EPS)diphenhydramine (Benadryl)
Fluorouracilleucoverin calcium
Heparinprotamine sulfate
HeroinNaloxone (Narcan) or Nalmefene
Insulin reactionglucose (Dextrose 50%)
IronDeferoxamine
Isoniazid, ethylene glycolPyridoxine HCl (Vitamin B6)
Leaddimercapol, edetate calcium, disodium,
Local anesthetics and possibly other cardiac toxins (e.g., bupropion, calcium channel blockers, cocaine, beta blockers, tricyclic antidepressants)Fat emulsion (Intralipid , Liposyn II , Liposyn III )
lovenoxprotamine sulfate
magnesium sulfatecalcium gluconate
magnesium sulfatecalcium gluconate
MethanolFolic acid
MethotrexateLeucovorin calcium
Narcotics, morphine sulfatenaloxone (Narcan)
Neuromuscular blockade (paralytics)anticholinesterase agents
Opioid analgesicsnalmefene or naloxone
Potassiumalbuterol inhaler, insulin & glucose, NaHCO3, kayexalate
Sodium channel blockers (e.g. cyclic antidepressants), salicylatesSodium Bicarbonate
SulfonylureasOctreotide (Sandostatin )
Tricyclic antidepressantsphyostigmine or NaHCO3
Valproic acidL-Carnitine