Common Drugs & Their Antidotes

Drug Antidote
Acetaminophen/Tylenol/Paracetamol acetylcysteine (Mucomyst)
Anticholinergics, diphenhydramine, dimenhydrinate Physostigmine
Anticholinesterase atrophine sulfate or pralidoxime
Antifreeze Fomepizole, Ethanol
Arsenic, Copper, Lead, Mercury D-Penicillamine (Cuprimine )
Benzodiazepines flumazenil
Beta-Blocking agents, Calcium channel blockers, Hypoglycemia, Hypoglycemic agents Glucagon, Epinephrine
Calcium Channel Blockers Calcium Chloride, Glucagon
Coumadin/Warfarin Phytonadione or Vitamin K
Cyanide Amyl nitrite, sodium nitrite, sodium thiosulfate
Cyclophosphamide Mesna
Digoxin Digibind or Digoxin Immune Fab
Dopamine phentolamie (Regitine)
Ethylene glycol fomepizole
ethyllene poisoning antizol
Extrapyramidal symptoms (EPS) diphenhydramine (Benadryl)
Fluorouracil leucoverin calcium
Heparin protamine sulfate
Heroin Naloxone (Narcan) or Nalmefene
Insulin reaction glucose (Dextrose 50%)
Iron Deferoxamine
Isoniazid, ethylene glycol Pyridoxine HCl (Vitamin B6)
Lead dimercapol, edetate calcium, disodium,
Local anesthetics and possibly other cardiac toxins (e.g., bupropion, calcium channel blockers, cocaine, beta blockers, tricyclic antidepressants) Fat emulsion (Intralipid , Liposyn II , Liposyn III )
lovenox protamine sulfate
magnesium sulfate calcium gluconate
magnesium sulfate calcium gluconate
Methanol Folic acid
Methotrexate Leucovorin calcium
Narcotics, morphine sulfate naloxone (Narcan)
Neuromuscular blockade (paralytics) anticholinesterase agents
Opioid analgesics nalmefene or naloxone
Potassium albuterol inhaler, insulin & glucose, NaHCO3, kayexalate
Sodium channel blockers (e.g. cyclic antidepressants), salicylates Sodium Bicarbonate
Sulfonylureas Octreotide (Sandostatin )
Tricyclic antidepressants phyostigmine or NaHCO3
Valproic acid L-Carnitine
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