| Drug | Antidote |
| Acetaminophen/Tylenol/Paracetamol | acetylcysteine (Mucomyst) |
| Anticholinergics, diphenhydramine, dimenhydrinate | Physostigmine |
| Anticholinesterase | atrophine sulfate or pralidoxime |
| Antifreeze | Fomepizole, Ethanol |
| Arsenic, Copper, Lead, Mercury | D-Penicillamine (Cuprimine ) |
| Benzodiazepines | flumazenil |
| Beta-Blocking agents, Calcium channel blockers, Hypoglycemia, Hypoglycemic agents | Glucagon, Epinephrine |
| Calcium Channel Blockers | Calcium Chloride, Glucagon |
| Coumadin/Warfarin | Phytonadione or Vitamin K |
| Cyanide | Amyl nitrite, sodium nitrite, sodium thiosulfate |
| Cyclophosphamide | Mesna |
| Digoxin | Digibind or Digoxin Immune Fab |
| Dopamine | phentolamie (Regitine) |
| Ethylene glycol | fomepizole |
| ethyllene poisoning | antizol |
| Extrapyramidal symptoms (EPS) | diphenhydramine (Benadryl) |
| Fluorouracil | leucoverin calcium |
| Heparin | protamine sulfate |
| Heroin | Naloxone (Narcan) or Nalmefene |
| Insulin reaction | glucose (Dextrose 50%) |
| Iron | Deferoxamine |
| Isoniazid, ethylene glycol | Pyridoxine HCl (Vitamin B6) |
| Lead | dimercapol, edetate calcium, disodium, |
| Local anesthetics and possibly other cardiac toxins (e.g., bupropion, calcium channel blockers, cocaine, beta blockers, tricyclic antidepressants) | Fat emulsion (Intralipid , Liposyn II , Liposyn III ) |
| lovenox | protamine sulfate |
| magnesium sulfate | calcium gluconate |
| magnesium sulfate | calcium gluconate |
| Methanol | Folic acid |
| Methotrexate | Leucovorin calcium |
| Narcotics, morphine sulfate | naloxone (Narcan) |
| Neuromuscular blockade (paralytics) | anticholinesterase agents |
| Opioid analgesics | nalmefene or naloxone |
| Potassium | albuterol inhaler, insulin & glucose, NaHCO3, kayexalate |
| Sodium channel blockers (e.g. cyclic antidepressants), salicylates | Sodium Bicarbonate |
| Sulfonylureas | Octreotide (Sandostatin ) |
| Tricyclic antidepressants | phyostigmine or NaHCO3 |
| Valproic acid | L-Carnitine |
