Generic Name : cefprozil
Brand Name: Cefzil
Classification: Antibiotic, Cephalosporin (second generation)
Pregnancy Category B
Dosage & Route
- Skin and soft tissue infections, Susceptible infections including upper and lower respiratory infections
- Adult: 500 mg/day as a single dose or in 2 divided doses, increased to 500 mg bid if necessary.
- Child: 20 mg/kg/day once or twice daily, up to a max dose of 500 mg once daily, if necessary, bid for otitis media.
- Cefprozil inhibits cell wall synthesis and has activity against a broad range of gram-positive and gram-negative bacteria.
- Absorption: Well absorbed from the GI tract. Bioavailability: 90-95%.
- Distribution: 35-45% bound to plasma proteins. Widely distributed in the body tissues.
- Excretion: Plasma half-life: 1-1.4 hr; prolonged in renal impairment. About 60% excreted unchanged in the urine.
- Pharyngitis or tonsillitis caused by Streptococcus pyogenes
- Secondary bacterial infection of acute bronchitis and exacerbation of chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
- Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
- Otitis media caused by S. pneumoniae, H. influenzae, M. catarrhalis
- Acute sinusitis caused by S. pneumoniae, S. aureus, H. influenzae, M. catarrhalis
- Nausea; vomiting; diarrhea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; hematologic disorders; pain at Injection site (IM); thrombophlebitis (IV infusion); superinfection with prolonged use.
- Potentially Fatal: Pseudomembranous colitis.
- History: Penicillin or cephalosporin allergy, pregnancy or lactation, renal failure
- Physical: Renal function tests, respiratory status, skin status, culture and sensitivity tests of infected area
- Culture infection before drug therapy.
- Give drug with food to decrease GI discomfort.
- Refrigerate suspension after reconstitution, and discard after 14 days.
- Discontinue if hypersensitivity reaction occurs.
- Give the patient yogurt or buttermilk in case of diarrhea.
- Arrange for oral vancomycin for serious colitis that fails to respond to discontinuation.
- Take this drug with food.
- Complete the full course of this drug, even if you feel better.
- This drug is prescribed for this particular infection; do not use it to self-treat any other infection.
- You may experience these side effects: Stomach upset, loss of appetite, nausea (take drug with food); diarrhea; headache, dizziness.
- Report severe diarrhea with blood, pus, or mucus; rash or hives; difficulty breathing; unusual tiredness, fatigue; unusual bleeding or bruising.