Generic Name : ritonavir
Brand Name: Norvir
Pregnancy Category B
Dosage & Route
Available forms :Capsules—100 mg; oral solution—80 mg/mL
- 600 mg PO bid with food.
- Start at 250 mg/m2 PO bid and increase by 50 mg/m2 twice daily at 2–3 day intervals, to maximum of 400 mg/m2 PO bid; do not exceed 600 mg bid. Use in combination with other antiretrovirals.
- Ritonavir, a selectively competitive reversible inhibitor of HIV protease, interferes with the formation of essential proteins and enzymes. Afterwhich, the formation of immature and non-infectious viruses follows. It also interferes with the production of infectious HIV and limits further infectious spread of the virus.
- Treatment of HIV infection in combination with other antiretrovirals
- Syncope, orthostatic hypotension; dry mouth, mouth ulcers, throat irritation, cough; dyspepsia, nausea, vomiting, diarrhoea, taste disturbance, seizures, anxiety, sweating, fever, asthenia, fatigue, headache, dizziness, paraesthesia, myalgia, skin rashes, pruritus, renal insufficiency, anaemia, raised WBC, raised prothrombin time, lipodystrophy, pancreatitis, electrolyte imbalance.
- Potentially Fatal: Hypersensitivity, anaphylaxis and Stevens-Johnson syndrome.
- Hypersensitivity; lactation; severe hepatic impairment.
CLINICAL ALERT! Name confusion has been reported between Retrovir (zidovudine) and ritonavir; use caution.
- History: Allergy to ritonavir, hepatic dysfunction, pregnancy, lactation
- Physical: T; orientation, reflexes; BP, P, peripheral perfusion; R, adventitious sounds; bowel sounds; skin color, perfusion; LFTs
- Capsules and oral solution should be stored in refrigerator; solution may be refrigerated or left at room temperature if used within 30 days; protect from light and extreme heat.
- Administer with meals or food to increase absorption.
- BLACK BOX WARNING: Carefully screen drug history to avoid potentially dangerous drug interactions.
- Take this drug with meals or food; store capsules in refrigerator. Taste of solution may be improved if mixed with chocolate milk, Ensure, or Advera 1 hour before taking. Do not drink grapefruit juice while using this drug.
- Take the full course of therapy as prescribed; do not take double doses if one is missed; do not change dosage without consulting your health care provider. Always take in combination with your other HIV drugs.
- This drug does not cure HIV infection; long-term effects are not yet known; continue to take precautions as the risk of transmission is not reduced by this drug.
- Do not take any other drugs, prescription or over-the-counter, without consulting your health care provider; this drug interacts with many other drugs and serious problems can occur.
- You may experience these side effects: Nausea, vomiting, loss of appetite, diarrhea, abdominal pain, headache, dizziness, numbness, tingling.
- Report severe diarrhea, severe nausea, personality changes, changes in color of urine or stool, fever, chills.