Generic Name : diclofenac, diclofenac potassium, diclofenac sodium
Brand Name: Cataflam, Novo-Difenac-k (CAN), Voltaren Rapide (CAN), Novo-Difenac (CAN), Novo-Difenac SR (CAN), Nu-Diclo (CAN), Solaraze, Voltaren, Voltaren nu-Diclo SR (CAN), Ophtha (CAN), Voltaren-XR
Classification: Anti-inflammatory, NSAID
Pregnancy Category B
Dosage & Route
- Pain, including dysmenorrhea: 50 mg tid PO; initial dose of 100 mg may help some patients (Cataflam).
- Osteoarthritis: 100–150 mg/day PO in divided doses (Voltaren); 50 mg bid–tid PO (Cataflam).
- Rheumatoid arthritis: 150–200 mg/day PO in divided doses (Voltaren); 50 mg bid–tid PO (Cataflam).
- Ankylosing spondylitis: 100–125 mg/day PO. Give as 25 mg qid, with an extra 25-mg dose hs (Voltaren); 25 mg qid PO with an additional 25 mg at bedtime if needed (Cataflam).
- Actinic keratosis: Cover lesion with gel and smooth into skin; do not cover with dressings or cosmetics (Solaraze).
- 1 drop to affected eye qid starting 24 hr after surgery for 2 wk.
- Safety and efficacy not established.
- Diclofenac has potent anti-inflammatory, analgesic and antipyretic actions. It inhibits the enzyme, cyclooxygenase, thus resulting in reduced synthesis of prostaglandin precursors.
- Acute or long-term treatment of mild to moderate pain, including dysmenorrhea
- Rheumatoid arthritis
- Ankylosing spondylitis
- Treatment of actinic keratosis in conjunction with sun avoidance
- Ophthalmic: Postoperative inflammation from cataract extraction
- GI disturbances; headache, dizziness, rash; GI bleeding, peptic ulceration; abnormalities of kidney function. Pain and tissue damage at Inj site (IM); local irritation (rectal); transient burning and stinging (ophthalmic).
- Potentially Fatal: Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis.
- Active peptic ulcer; hypersensitivity to diclofenac or other NSAIDs. Treatment of perioperative pain in CABG surgery. 3rd trimester of pregnancy. Topical: Not to be applied onto damaged or nonintact skin.
- History: Renal impairment; impaired hearing; allergies; hepatic, CV, and GI conditions; lactation, pregnancy
- Physical: Skin color and lesions; orientation, reflexes, ophthalmologic and audiometric evaluation, peripheral sensation; P, edema; R, adventitious sounds; liver evaluation; CBC, clotting times, renal function tests, LFTs, serum electrolytes, stool guaiac
- BLACK BOX WARNING: Be aware that patient may be at increased risk for CV events, GI bleed, renal insufficiency; monitor accordingly.
- Administer drug with food or after meals if GI upset occurs.
- Arrange for periodic ophthalmologic examination during long-term therapy.
- WARNING: Institute emergency procedures if overdose occurs (gastric lavage, induction of emesis, supportive therapy).
- Take drug with food or meals if GI upset occurs.
- Take only the prescribed dosage.
- You may experience these side effects: Dizziness, drowsiness (avoid driving or using dangerous machinery while using this drug).
- Report sore throat, fever, rash, itching, weight gain, swelling in ankles or fingers, changes in vision; black, tarry stools.