Generic Name : zolpidem tartrate
Brand Name: Ambien, Ambien CR
Classification: Sedative or hypnotic (nonbarbiturate)
Pregnancy Category B (immediate-release)
Pregnancy Category C (extended-release)
Controlled Substance C-IV
Dosage & Route
Available forms :Tablets—5, 10 mg; ER tablets—6.25, 12.5 mg
- 10 mg PO at bedtime. Do not exceed 10 mg/day. ER tablets—12.5 mg/day PO.
- Safety and efficacy not established.
- Increased chance of confusion, acute brain syndrome; initiate treatment with 5 mg PO or 6.25 mg/day PO ER tablets.
- Zolpidem acts by binding to the benzodiazepine (BZD) receptors of the GABA receptor complex. It has a selective affinity to BZD receptors prevalent in the cerebellum (omega-1 receptors). It has strong sedative actions but only minor anxiolytic properties. It has also less effects on skeletal muscle and seizure threshold. Zolpidem has a rapid onset but short duration of hypnotic action.
- Short-term treatment of insomnia
- Treatment of insomnia in adults who experience difficulties with sleep onset and sleep maintenance (ER tablets)
- Amnesia, drowsiness, dizziness, diarrhea, nausea, vomiting, abnormal thinking and behavior, drugged feelings, back pain, ataxia, hiccups, confusion, euphoria, insomnia, vertigo, diplopia, abnormal vision.
- Potentially Fatal: Hepatitis, anaphylactic reactions, sleep-driving (driving while not fully awake after drug ingestion, with no recollection of the event).
- Severe hepatic insufficiency.
- History: Hypersensitivity to zolpidem, acute intermittent porphyria, impaired hepatic or renal function, addiction-prone patients, lactation, pregnancy
- Physical: T; skin color, lesions; orientation, affect, reflexes, vision examination; P, BP; bowel sounds, normal output, liver evaluation; CBC with differential; LFTs, renal function tests
- WARNING: Limit amount of drug dispensed to patients who are depressed or suicidal.
- WARNING: Withdraw drug gradually if patient has used drug long-term or if patient has developed tolerance. Supportive therapy similar to that for withdrawal from barbiturates may be necessary to prevent dangerous withdrawal symptoms.
- Take this drug exactly as prescribed. Do not exceed prescribed dosage. Long-term use is not recommended.
- You may experience these side effects: Drowsiness, dizziness, blurred vision (avoid driving or performing tasks requiring alertness or visual acuity); GI upset (eat frequent small meals).
- Report rash, sore throat, fever, bruising, complex sleep disorders.