Pharmacology Exam for Antifungal Drugs

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1. A patient receiving topical antifungal complains of blisters in her perineum. Which is/are a possible explanation(s) for this?

  1. Fungal infection is not healing.
  2. Patient is allergic to the drug.
  3. Both A and B
  4. None of the above

2. Which of the following will alert the nurse for possible adverse effect in patients receiving long-term itraconazole therapy?

  1. Central obesity
  2. Cataract
  3. Thickening of the skin
  4. Pathologic U wave

3. An eight (8) month old infant is receiving antifungals. Which should be included in the nurse’s health teaching to the mother?

  1. Cover the area of lesions with diaper to prevent additional infection.
  2. Make sure area is free from occlusive dressings.
  3. Apply more topical cream on draining areas because it is where fungi are most
  4. Advise that redness and rashes are negligible side effects of antifungal therapy and should not be a cause of worry.

4. Which of these antifungals can be used in pregnant women?

  1. Fluconazole
  2. Nystatin
  3. Ketoconazole
  4. Amphotericin B

5. Which antifungal can be used for patients who are undergoing hematopoietic stem cell transplant?

  1. Itraconazole
  2. Echinocandin antifungals
  3. Nystatin
  4. Gentian violet
Answers & Rationales

1. Answer: C. Both A and B. Development of rash, especially if accompanied by blisters and irritation signify worsening of condition and development of hypersensitivity reaction.

2. Answer: A. Central obesity. Ketoconazole, fluconazole, and itraconazole block the activity of a sterol in a fungal wall. Therefore, they may also block the activity of human steroids such as testosterone and cortisol.

3. Answer: B. Make sure area is free from occlusive dressings. This include tight diapers, which can facilitate systemic absorption and occurrence of drug adverse effects. Rashes can be a sign of allergy to the drug.

4. Answer: D. Amphotericin B

5. Answer: B. Echinocandin antifungals.