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1.Once a fetus is infected, it more more susceptible to infection due to its poor immunity and lack of synthesis of what antibody?
2. Molecules that can cause cellular defects in growth, i.e. induce fetal malformations, are known as
3. A distinguishing factor between viral teratogens (rubella) and other teratogens (drugs, radiation) would be that
- only viral teratogens cause retarded fetal growth
- fetal death is only a possibility with other teratogens, not viral
- maternal effects are only seen with viral teratogens
- genetic factors are not present with viral teratogens
4. Primary infection of the mother, rather than re-activation, tends to have a worse fetal consequence.
5. A fetus is particularly susceptible to rubella infection when maternal infection occurs during what stage of pregnancy?
- 1st trimester
- 2nd trimester
- 3rd trimester
- susceptibility unknown
6. Congenital rubella is associated with the development of what clinical condition in 80% of those infants infected?
- diabetes mellitus
7. What antibody, produced by the fetus, can be detected in the cord blood of an infant infected with the rubella virus?
8. Congenital rubella is completely preventable by
- having a superb immune system
9. A primary CMV infection occurring during the first trimester is associated with sensorineural hearing loss, more specifically associated with what cranial nerve?
- CN IV
- CN V
- CN VI
- CN VIII
10.Clinical features such as hepatosplenomegaly, skin and mucosal lesions, and a saddle-shaped nose are associated with what congenital infection?
- congenital rubella
- congenital CMV
- congenital syphilis
- congenital HIV
Answer & Rationale
- C. IgG
- B. teratogens
- D. genetic factors are not present with viral teratogens
- A. True
- A. 1st trimester.During the first 3 months, organ development occurs. virus interfere with development of heart, brain, eyes and ears
- B. deafness
- D. IgM
- B. vaccination
- D. CN VIII
- C. congenital syphilis