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1.Once a fetus is infected, it more more susceptible to infection due to its poor immunity and lack of synthesis of what antibody?
- IgA
- IgD
- IgG
- IgM
2. Molecules that can cause cellular defects in growth, i.e. induce fetal malformations, are known as
- secretagogues
- teratogens
- hematotrophic
- cytopathogenic
3. A distinguishing factor between viral teratogens (rubella) and other teratogens (drugs, radiation) would be that
- only viral teratogens cause retarded fetal growth
- fetal death is only a possibility with other teratogens, not viral
- maternal effects are only seen with viral teratogens
- genetic factors are not present with viral teratogens
4. Primary infection of the mother, rather than re-activation, tends to have a worse fetal consequence.
- True
- False
5. A fetus is particularly susceptible to rubella infection when maternal infection occurs during what stage of pregnancy?
- 1st trimester
- 2nd trimester
- 3rd trimester
- susceptibility unknown
6. Congenital rubella is associated with the development of what clinical condition in 80% of those infants infected?
- blindness
- deafness
- obesity
- diabetes mellitus
7. What antibody, produced by the fetus, can be detected in the cord blood of an infant infected with the rubella virus?
- IgA
- IgD
- IgG
- IgM
8. Congenital rubella is completely preventable by
- isolation
- vaccination
- having a superb immune system
9. A primary CMV infection occurring during the first trimester is associated with sensorineural hearing loss, more specifically associated with what cranial nerve?
- CN IV
- CN V
- CN VI
- CN VIII
10.Clinical features such as hepatosplenomegaly, skin and mucosal lesions, and a saddle-shaped nose are associated with what congenital infection?
- congenital rubella
- congenital CMV
- congenital syphilis
- congenital HIV
Answer & Rationale
- C. IgG
- B. teratogens
- D. genetic factors are not present with viral teratogens
- A. True
- A. 1st trimester.During the first 3 months, organ development occurs. virus interfere with development of heart, brain, eyes and ears
- B. deafness
- D. IgM
- B. vaccination
- D. CN VIII
- C. congenital syphilis